Four Supplements Against Estrogen Dominance

Estrogen dominance means you have too much estrogen for the progesterone you produce. Even if your blood panel shows both hormones within the normal range, you may have symptoms of estrogen dominance if your estradiol (the main estrogen) is on the upper end of the spectrum and your progesterone on the lower end. To tackle estrogen dominance problem you may need:

  1. To increase your progesterone production.
  2. To clear up old estrogen more efficiently, so it doesn’t accumulate in your body.
  3. To normalize the amount of estrogen you produce.

The first steps in balancing estrogen dominance are eating an anti-inflammatory diet with low glycemic index and sleeping enough. These two things are key against estrogen dominance or any hormonal imbalance. Aside from that, you can also consider the following supplements with your doctor:

Supplements that help increase your progesterone:

  1. Vitex or Chaste berry: the berry of Vitex agnus castus, also known as Chaste berry has clinically shown to normalize progesterone levels. (1) Some uncontrolled studies even show chaste berry significantly improving infertility due to low progesterone (2). Thanks to its ability to increase progesterone, Vitex is considered by many herbalist and integrative practitioners as the first line of treatment for most cycle imbalances. So if your progesterone is on the lower end of the spectrum, Vitex it’s worth a try.
  2. A strong adaptogen: If you have too much stress, you can’t produce progesterone, it doesn’t matter how much Vitex you take. Why? because cortisol (the stress hormone) and progesterone develop from the same molecules. If you are stressed out, the “ingredients” to form progesterone get used up before this wonderful hormone has the chance to develop. Adaptogens make your body more resistant to stress, diminishing its negative effects on your body. (3) That’s why people with progesterone insufficiency would benefit from including an adaptogen in their routines.

Supplements that help clear-up excess estrogen more efficiently:

  1. Reishi and dandelion root: one of the causes of oestrogen dominance is low liver detoxification of old oestrogen. Both reishi and dandelion root have molecules shown to improve liver health (4) (5) (6) (7) (8).
  2. Di-indolyl-methane (DIM): this compound is naturally found in broccoli and other cruciferous vegetables. It allows for the methylation of estrogen (9). Methylated estrogen is good for you: it’s very anticancer and makes your bones strong. Unmethylated estrogen on the other hand turns into estrogen forms related to breast and ovarian cancer. DIM also seems to protect against the bad effects of endocrine disruptive chemicals such as BPA or triclosan. (10) The best way to take DIM is through cruciferous vegetables (cauliflower, kale, Brussel sprouts, etc.) but you can also take it as a supplement to be sure you have DIM available even on those days you don’t feel like eating kale.

Remember that this is not medical advice, but rather a guide of some possible supplements to consider. Check with your doctor before introducing any new supplement to your routine.

  1. Milewicz A. Vitex agnus castus extract in the treatment of luteal phase defects due to hyperprolactinemia: results of a randomized placebo-controlled double-blind study. Arzneim-Forsch Drug Res . 1993;43(7):752–756.
  2. Romm AJ. Botanical Medicine for Women's Health, 2nd Edition,
  3. Panossian A, Wikman G, Kaur P, Asea A. Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones. Phytomedicine. 2009;16(6-7):617-622. doi:10.1016/j.phymed.2008.12.003.
  4. Chiu HF, Fu HY, Lu YY, et al. Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum : a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers. Pharmaceutical Biology. 2017;55(1):1041-1046. doi:10.1080/13880209.2017.1288750
  5. Soares AA, de Sá-Nakanishi AB, Bracht A, da Costa SM, Koehnlein EA, de Souza CG, Peralta RM. Hepatoprotective effects of mushrooms. Molecules. 2013 Jul 1;18(7):7609-30. doi: 10.3390/molecules18077609. PMID: 23884116; PMCID: PMC6270077.
  6. Pfingstgraf IO, Taulescu M, Pop RM, Orăsan R, Vlase L, Uifalean A, Todea D, Alexescu T, Toma C, Pârvu AE. Protective Effects of Taraxacum officinale L. (Dandelion) Root Extract in Experimental Acute on Chronic Liver Failure. Antioxidants (Basel). 2021 Mar 24;10(4):504. doi: 10.3390/antiox10040504. PMID: 33804908; PMCID: PMC8063808.
  7. Schütz K, Carle R, Schieber A. Taraxacum--a review on its phytochemical and pharmacological profile. J Ethnopharmacol. 2006 Oct 11;107(3):313-23. doi: 10.1016/j.jep.2006.07.021. Epub 2006 Jul 22. PMID: 16950583.-8^
  8. Cai L, Wan D, Yi F, Luan L. Purification, Preliminary Characterization and Hepatoprotective Effects of Polysaccharides from Dandelion Root. Molecules. 2017 Aug 25;22(9):1409. doi: 10.3390/molecules22091409. PMID: 28841174; PMCID: PMC6151742.
  9. Auborn KJ, Fan S, Rosen EM, Goodwin L, Chandraskaren A, Williams DE, Chen D, Carter TH. Indole-3-carbinol is a negative regulator of estrogen. J Nutr. 2003 Jul;133(7 Suppl):2470S-2475S. doi: 10.1093/jn/133.7.2470s. PMID: 12840226.
  10. Younas M, Hano C, Giglioli-Guivarc'h N, Abbasi BH. Mechanistic evaluation of phytochemicals in breast cancer remedy: current understanding and future perspectives. RSC Adv. 2018 Aug 22;8(52):29714-29744. doi: 10.1039/c8ra04879g. PMID: 35547279; PMCID: PMC9085387.

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